Dr. ÁDÁM STURM
Research
Aging; DNA methylation (epigenetics); CRISPR / Cas9 techniques;
Deep-neural networks, Molecular cloning, Bioinformatics,
Next-generation sequencing
Experiences
Semmelweis University (Institute for Pathology and Experimental Cancer Research, Number I, 2016-)
Examination of the role of transposons in cancer
Velgene Three Kft. (2014 - 2016)
Examination of the role of transposons in cancer
ELTE MSc and PhD (Department of Genetics, 2012 -)
Research on the theory of aging based on transposable elements and development of RNA interference and Cas9 / CRISPR in C. elegans. Deep neural network development
MTA TTK (Biomembrane Group, 2013 - 2016)
Developing CRISPR / Cas9 techniques
Paul-Ehrlich-Institut (Department of Medical Biotechnology, 2013)
Research and cooperation on aging theory based on transposable elements
MTA SZTAKI
Deep neural network development. Convolution machine learning and gradient boosting development
Deep Biotech Solutions Ltd.
Deep neural network, Cas9 / CRISPR, Molecular cloning,
Bioinformatics, Next-generation sequencing
Studies
ELTE TTK PhD (2013-2019)
Department of Genetics
ELTE TTK MSc (2012-2013)
Molecular Genetics, Cell and Development Science
ELTE TTK BSc (2007–2012)
Biology
Publications
1. Sturm, A., Ivics, Z. and Vellai, T. (2015) The mechanism of ageing: primary role of transposable elements in genome disintegration. Cellular and molecular life sciences : CMLS, 72, 1839-1847.
2. Sturm, A., Perczel, A., Ivics, Z. and Vellai, T. (2017) The Piwi-piRNA pathway: road to immortality. Aging cell, 16, 906-911.
3. Sturm, A., Saskoi, E., Tibor, K., Weinhardt, N. and Vellai, T. (2018) Highly efficient RNAi and Cas9-based auto-cloning systems for C. elegans research. Nucleic Acids Research, Manuscript ID NAR-02888-Met-G-2017.R1
4. Talas, A., Kulcsar, P.I., Weinhardt, N., Borsy, A., Toth, E., Szebenyi, K., Krausz, S.L., Huszar, K., Vida, I., Sturm, A. et al. (2017) A convenient method to pre-screen candidate guide RNAs for CRISPR/Cas9 gene editing by NHEJ-mediated integration of a 'self-cleaving' GFP-expression plasmid. DNA research : an international journal for rapid publication of reports on genes and genomes.
5. Csaba Kerepesi, Bálint Daróczy, Ádám Sturm, Tibor Vellai & András Benczúr (2018) Prediction and characterization of human ageing-related proteins by using machine learning. Scientific reports. doi:10.1038/s41598-018-22240-w
6. Sturm, Á., Saskői, É., Hotzi, B. et al. Downregulation of transposable elements extends lifespan in Caenorhabditis elegans. Nat Commun 14, 5278 (2023). https://doi.org/10.1038/s41467-023-40957-9